Correction: Nucleosomes Correlate with In Vivo Progression Pattern of De Novo Methylation of p16 CpG Islands in Human Gastric Carcinogenesis
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چکیده
the number of PCR products that exhibited methylated-and unmethylated-p16 of two representative GC samples as determined using the 83bp-MSP assay. The lower panel compares the detection of methylated-p16 in 61 gastric tissue samples using the 83bp-MSP and sMSP assays. The table indicated that the results of the 83bp-MSP correlated with those of sMSP significantly (p<0.04).
منابع مشابه
Nucleosomes Correlate with In Vivo Progression Pattern of De Novo Methylation of p16 CpG Islands in Human Gastric Carcinogenesis
BACKGROUND The exact relationship between nucleosome positioning and methylation of CpG islands in human pathogenesis is unknown. METHODOLOGY/PRINCIPAL FINDINGS In the present study, we characterized the nucleosome position within the p16 CpG island and established a seeding methylation-specific PCR (sMSP) assay based on bisulfite modification to enrich the p16 alleles containing methylated-C...
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